A DYRK1A-TGFβ Signaling Axis Determines Sensitivity to OXPHOS Inhibition in Hepatocellular Carcinoma
收藏国家人口健康科学数据中心2026-06-06 收录
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资源简介：
Cao et al. find DYRK1A-TGFβ signaling axis determines sensitivity to OXPHOS inhibition in HCC cancer cells, and targeting DYRK1A combined with IACS-010759 demonstrates therapeutic efficacy in multiple liver cancer models. Mechanistically, DYRK1A phosphorylates SMAD3 at Thr132, suppressing the negative impact of TGFβ signaling on SLC1A5 transcription.
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北京蛋白质组研究中心创建时间：
2024-12-04
