Asymmetric Synthesis of Enantioenriched 6‑Hydroxyl Butyrolactams Promoted by N‑Heterocyclic Carbene
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Herein, an efficient route to synthesize 6-hydroxyl butyrolactams has been successfully developed via an N-heterocyclic carbene-catalyzed formal [3 + 2] annulation of bromoenals with α-amino ketones, followed by reduction. Remarkably, enantioenriched epi-neoclausenamide, which is one of the clausenamide derivatives, could be efficiently prepared by this strategy.
创建时间：
2019-07-22
