Epigenetic modification of Blood brain barrier in aging and stroke

Epigenetics has emerged as an important contributor to Blood brain barrier injury in many diseases. This study aimed to evaluate the epigenetic (methylome) and transcriptional landscapes of poststroke BBB recovery that could define the plasticity and capacity for BBB restoration after stroke. As aging has critical roles in stroke occurrence, outcomes and recovery, this study examines the methylome and transcriptome signatures of poststroke BBB recovery in young and old mice, highlighting age-related processes and factors that could affect capacity for BBB restoration.