VNN1-Driven ERK Pathway Activation in Ulcerative Colitis Progression Revealed by Machine Learning and Mendelian Randomization
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项目二课题三2024年年度计划
年度指标：（1）获得非标记和同位素标记的生物酶试验样品，包括酶的表达载体构建，表达条件优化及筛选，制备可供NMR测量的酶样品；（2）构建用于环境模拟研究的生物酶的初始结构，探索类细胞环境的计算机模拟实验；（3）优化开展NMR等实验的合适条件，初步残基NMR数据；（4）建立酶催化体系的拥挤、限域等类细胞环境，探索别构效应诱发条件，测试相应条件下酶活性变化。
中国科学院兰州化学物理研究所科学数据中心2026-01-09 更新130
OTUD3 prevents ulcerative colitis by modulating microbiota-mediated STING activation
Human intestinal Thy1+ mesenchymal cells are considered as heterogeneous population. We performed single cell RNA sequencing (scRNA-seq) to characterize fibroblast populations in the colonic mucosa.Li
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Values of the parameter f1 in the model extension.
f1 values for model extension with cell cycle arrest species. Same experimental data as in Table 1. For all simulations parameter r = rmax is set to 0.70 determined for HeLa cell growth rate and param
Figshare2015-12-02 更新10
Gene Expression Profiling of Ulcerative Colitis
Through laser capture microdissection and microarray analysis combined with slightly modified RNA extraction and amplification. we could analyze the subtle differential expression between colon norm
NIAID Data Ecosystem60
Data_Sheet_4_Lnc-ITSN1-2, Derived From RNA Sequencing, Correlates With Increased Disease Risk, Activity and Promotes CD4+ T Cell Activation, Proliferation and Th1/Th17 Cell Differentiation by Serving as a ceRNA for IL-23R via Sponging miR-125a in Inflammatory Bowel Disease.zip
Background: This study aimed to investigate long-non-coding RNA (lncRNA) expression profiles and the correlation of lnc-ITSN1-2 expression with disease risk, activity and inflammation, and its influen
NIAID Data Ecosystem30
