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Calculated DAR of thermally stressed ARX788 drug product by HIC-HPLC.

Figshare2023-07-10 更新2026-04-28 收录

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https://figshare.com/articles/dataset/Calculated_DAR_of_thermally_stressed_ARX788_drug_product_by_HIC-HPLC_/23655453 数据链接链接失效反馈

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Calculated DAR of thermally stressed ARX788 drug product by HIC-HPLC.

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2023-07-10

抗体药物偶联物效力

药物抗体比分析

The percentage of intact MMAD was calculated as the ratio of treated DAR to untreated DAR. Degradation of the C-terminal portion of the PEG6-C2-MMAD payload is considered equivalent to payload removal

NIAID Data Ecosystem70

Extended data Fig. 9b supprimé

抗体药物偶联物效力

流式细胞术

The potency of MICAB1 PBD2G-ADCs, expressed as the IC50 (µg/ml) value, was determined in cytotoxicity assays. Antibody Binding Capacity (ABC), correlated to the number of MICA molecules expressed at t

NIAID Data Ecosystem20

Extended data Fig. 9b

抗体药物偶联物效力

细胞表面标志物

The potency of MICAB1 PBD2G-ADCs, expressed as the IC 50 (µg/ml) value, was determined in cytotoxicity assays. Antibody Binding Capacity (ABC), correlated to the number of MICA molecules exp

Figshare2021-08-07 更新10

IC50 values (pM) of SG3552-based toxins and ADCs against T.brucei cell lines and a human Jurkat cell line.

克氏锥虫药物筛选

抗体药物偶联物效力

The IC50 values of toxin SG3552, toxin plus linker SG3376, a control ADC (NIP228-SG3376) and two anti-trypanosome ADCs targeting the T. b. brucei HpHbR (Tb074-SG3376 and Tb085-SG3376) against T. b bru

Figshare2019-05-23 更新20

Antibody-drug conjugate stability probed by variable-temperature electrospray ionization mass spectrometry

抗体药物偶联物效力

质谱分析

The stability of hinge-deleted and mutated IgG4, as well as lysine- (Trastuzumab emtansine) and cysteine-based ADCs (Enfortumab vedotin, Brentuximab vedotin) was probed with vT-ESI-MS.

NIAID Data Ecosystem20

Calculated DAR of thermally stressed ARX788 drug product by HIC-HPLC.

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