Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages

ChEBI2016-06-29 更新2026-07-12 收录

蛋白酶体功能

肺泡巨噬细胞

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Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages

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2016-06-29

Serotonin stimulation of alveolar macrophages from wild type and 5-HT2C deficient animals. Mus musculus

神经免疫学

肺泡巨噬细胞

Gene regulation upon serotonin stimulation was compared in wild-type and 5HT2C receptor kock-out mice. Serotonin (5-HT), known as neuromodulator, regulates immune responses and inflammatory cascades.

NIAID Data Ecosystem80

The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation. Schizosaccharomyces pombe

染色质调控

蛋白酶体功能

The non-proteolytic role of the proteasome in heterochromatin regulation Overall design: For ChIP experiment : ChIP against H3K9me2, anti-FLAG was performed for a wild type strain and strains lacking

NIAID Data Ecosystem70

Immunoproteasome assembly and antigen presentation in mice lacking both PA28α and PA28β

蛋白酶体功能

抗原特异性加工

Two members of the proteasome activator, PA28α and PA28β, form a heteropolymer that binds to both ends of the 20S proteasome. Evidence in vitro indicates that this interferon-γ (IFN-γ)-inducible heter

PubMed Central2001-11-01 更新40

Table_6_Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation.xlsx

COPD免疫病理

肺泡巨噬细胞

Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in cellular

NIAID Data Ecosystem70

SARS-CoV-2 Evades Immune Detection in Alveolar Macrophages

病毒免疫逃逸

肺泡巨噬细胞

Respiratory infections, like the current COVID-19 pandemic, target epithelial cells in the respiratory tract. Alveolar macrophages (AMs) are tissue-resident macrophages located within the lung. They p

NIAID Data Ecosystem40

Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages

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