A conserved eag domain in the cytoplasmic amino terminus of the human ether-a-go-go-related gene (hERG) potassium channel is critical for its slow deactivation gating. Introduction of gene fragments e
KI) and the free energy for inactivation gate closure (ΔGinactivation), for all single-, double- and triple-mutants used to calculate the coupling free energies during inactivation gating.a The table
Magnesium ions (Mg2+) are divalent cations essential for various cellular functions. Mg2+ homeostasis is maintained through Mg2+ channels such as MgtE, a prokaryotic Mg2+ channel whose gating is regul
