Crystal structure of the HPK1 kinase domain in complex with inhibitor 12
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Crystal structure of the HPK1 kinase domain in complex with inhibitor 12 Descriptor: 1,2-ETHANEDIOL, 2-cyclopropyl-8-(3-methoxy-1-methyl-pyrazol-4-yl)-3-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrido[3,4-b]pyrazin-5-amine, Mitogen-activated protein kinase kinase kinase kinase 1 Authors: Schimpl, M, Richter, M. Deposit date: 2026-06-25 Release date: 2026-08-05 Last modified: 2026-08-26 Method: X-RAY DIFFRACTION (1.386 Å) Cite: Generative AI-Assisted Discovery of HPK1 Inhibitors. J.Med.Chem., 69, 2026
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2026-06-25
