Bojungikki-tang ameliorates psoriasis-like dermatitis: Network analysis and transcriptomics with experimental validation

Psoriasis is a chronic and complex disease characterized by itching, burning, and soreness with scaly plaques and erythematous lesions. we evaluated the effect of Bojungikki-tang (BJT, Buzhong-Yiqi-Tang in traditional Chinese medicine and Hochu-ekki-to in Kampo medicine) as a combination of medicinal herbs against psoriasis. Network analysis from transcriptomics was used to determine the effective phytochemical constituents of BJT. Overall design: To identify the protective effect of BJT on psoriasis-like skin inflammation, topical imiquimod (IMQ)-applied mice were administered with BJT (250, 500, or 1000 mg/kg/day) or MTX (1 mg/kg/day) orally for 7 days.