Analysis of differentially expressed long noncoding RNAs, circular RNAs and the associated TF-mRNA network in tongue squamous cell carcinoma

Purpose: The purpose of this study was to identify aberrantly expressed lncRNAs, circular RNAs and the associated TF-mRNA network in TSCC. Methods: Tongue tumor noncoding and mRNA profiles of tongue squamous cell carcinoma and adjacent noncancerous tissues were generated by deep sequencing, using Illumina HiSeq 4000. Results: Using an optimized data analysis workflow. Conclusions: we found a profile of dysregulated lncRNAs, TFs and mRNAs that could serve as prospective clinical biomarkers because of their tissue specificity and association with the tumorigenesis and progression of TSCC. Overall design: tongue tumor noncoding and mRNA profiles of tongue squamous cell carcinoma and adjacent noncancerous tissues were generated by deep sequencing, in triplicate, using Illumina HiSeq 4000