Human herpes simplex virus-1 (HSV-1) encephalitis can be caused by inborn errors of the TLR3 pathway resulting in impairment of central nervous system (CNS) cell-intrinsic antiviral immunity. Deficien
Precise control of the innate immune response is required for resistance to microbial infections and maintenance of normal tissue homeostasis. Because this response involves coordinate regulation of h
Cytokine response of PMNs and macrophages to Zymosan and Pam3Cys. In vitro cytokine responses to non-TLR4 agonists of elicited peritoneal phagocytes from Wt or TLR4 mut mice. PMNs (A–D) and macrophage
Crystal structure of human cGAS apo form Descriptor: Cyclic GMP-AMP synthase, ZINC ION Authors: Kato, K, Ishii, R, Ishitani, R, Nureki, O. Deposit date: 2013-09-05 Release date: 2013-10-30 Last modifi
Spinal muscular atrophy (SMA) is an autosomal recessive, pediatric-onset disorder caused by the loss of spinal motor neurons thereby leading to generalized muscle atrophy. SMA is caused by the loss of