Crystal structure of human KRAS G12C covalently bound to 1,4-dimethyl-pyrazol-5-yl piperidine compound 5
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Crystal structure of human KRAS G12C covalently bound to 1,4-dimethyl-pyrazol-5-yl piperidine compound 5 Descriptor: 1,2-ETHANEDIOL, 1-[4-(1-{6-[4-(1,4-dimethyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}azetidin-3-yl)piperazin-1-yl]propan-1-one, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Mohr, C. Deposit date: 2026-04-10 Release date: 2026-08-12 Last modified: 2026-08-26 Method: X-RAY DIFFRACTION (1.26 Å) Cite: Property-Biased Covalent DNA-Encoded Library Screening Enabled the Discovery of AM-8719, A Structurally Novel, CNS-Penetrant KRAS G12C Inhibitor. J.Med.Chem., 69, 2026
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2026-04-10
