膨腹海马对高尿酸血症小鼠降尿酸及肾保护作用研究数据集

该数据集包括膨腹海马及其提取物降尿酸作用相关数据。研究数据显示，膨腹海马显著降低HUA模型小鼠血尿酸、血尿素氮、血肌酐及肝脏中XOD活性，并能明显改善HUA小鼠肾小管与肾小球肿大、结构紊乱。根据研究发现，阳性药组别嘌呤醇小鼠会引起肾小管的上皮细胞的肾毒性，相对比别嘌呤醇，膨腹海马中，高剂量有明显显著改善肾损伤，且具有剂量依赖性。该数据集可为膨腹海马降尿酸产品的开发和利用提供数据支持。This dataset contains data regarding the urate-lowering effects of Hippocampus abdominalis and its extracts. Research findings indicate that Hippocampus abdominalis significantly reduced the levels of blood uric acid (BUA), blood urea nitrogen (BUN), serum creatinine (Scr), and xanthine oxidase (XOD) activity in the liver of hyperuricemia (HUA) model mice, and markedly ameliorated the swelling and structural disorganization of renal tubules and glomeruli in these HUA mice. Moreover, allopurinol, the positive control drug, induced nephrotoxicity in the renal tubular epithelial cells of the model mice. Compared with allopurinol, the high-dose Hippocampus abdominalis extract group achieved significantly better improvement in renal injury and displayed a distinct dose-dependent effect. This dataset can provide reliable data support for the development and utilization of urate-lowering products developed from Hippocampus abdominalis.

搜集汇总

背景与挑战

背景概述

该数据集包含膨腹海马及其提取物对高尿酸血症小鼠降尿酸及肾保护作用的研究数据，显示膨腹海马能显著降低小鼠血尿酸等指标并改善肾损伤，效果优于别嘌呤醇且具有剂量依赖性，为相关产品开发提供数据支持。