Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein

Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein Descriptor: (5S)-5-[(3R)-4,4-difluoro-3-hydroxy-4-phenylbutyl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-one, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Huang, S.M, Xiong, M.Y, Liu, L, Mu, J, Sheng, C, Sun, J. Deposit date: 2023-03-02 Release date: 2024-01-03 Last modified: 2024-10-30 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023