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Additional file 2 of LSD1 inhibition attenuates targeted therapy-induced lineage plasticity in BRAF mutant colorectal cancer

NIAID Data Ecosystem2026-05-02 收录

癌细胞耐药性

结直肠癌分子机制

数据链接：

https://figshare.com/articles/dataset/Additional_file_2_of_LSD1_inhibition_attenuates_targeted_therapy-induced_lineage_plasticity_in_BRAF_mutant_colorectal_cancer/28845576 数据链接链接失效反馈

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资源简介：

Supplementary Material 2

应用场景：

创建时间：

2025-04-23

癌细胞耐药性

癌症预后模型

Background: Liver cancer is a lethal cancer type among which hepatocellular carcinoma (HCC) is the most common manifestation globally. Drug resistance is a central problem impeding the efficiency of H

NIAID Data Ecosystem40

Effect of depletion of C15ORF48/miR-147 on gene expression in primary colonocytes [HCT116]

炎症调控

结直肠癌分子机制

Chronic inflammation is epidemiologically linked to the pathogenesis of gastrointestinal diseases, including inflammatory bowel disease (IBD) and colorectal cancer (CRC). However, our understanding of

NIAID Data Ecosystem30

Supplement 3. sgRNA sequences used for second round screen. from CRISPR Genome-Wide Screening Identifies Dependence on the Proteasome Subunit PSMC6 for Bortezomib Sensitivity in Multiple Myeloma

功能基因组筛选

癌细胞耐药性

The 31 most abundant of these sgRNAs found in cells surviving BTZ treatment were selected for secondary screening (Figure 2B). Each of the 31 potential BTZ resistance inducing genes was targeted by fo

NIAID Data Ecosystem20

A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance

癌细胞耐药性

靶向药物开发

This study identifies phosphorylation of SHP2 at tyrosine 62 (pY62) as a conserved mechanism of resistance to allosteric SHP2 inhibitors. By stabilizing an open, active SHP2 conformation, pY62 phenoco

DataCite Commons2026-04-10 更新30

Next Generation Sequencing Facilitates Quantitative Analysis of Transcriptomes in negative control and miR-1290 knockdown HCT116 cells

结直肠癌分子机制

MicroRNA功能研究

Colorectal cancer (CRC) ranks third in incidence and second in mortality among cancers worldwide. Emerging researches showed that microRNAs (miRNAs) play an important role in CRC progression. Here, we

NIAID Data Ecosystem30

Additional file 2 of LSD1 inhibition attenuates targeted therapy-induced lineage plasticity in BRAF mutant colorectal cancer

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