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资源简介：
Mitochondrial genome editing using CRISPR/Cas9-based base editing technology
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创建时间：
2022-03-31
相关数据集
MitoKO: A library of base editors for precise ablation of all protein-coding genes in the mouse mitochondrial genome
We design and apply a highly optimized library of double-stranded DNA deaminase (DddA)-derived cytosine base editors (DdCBEs) - MitoKO - to precisely ablate every mtDNA protein coding gene in the mous
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Modeling High-grade serous ovarian carcinoma using a combination of in vivo fallopian tube electroporation and CRISPR/Cas9-mediated genome editing
In this study we generated a mouse model of high-grade serous ovarian carcinoma by targeting tumor suppressor genes Brca1, P53 and Pten using CRISPR/Cas9. The addition of Lkb1 to this combination redu
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mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels
This work describes the development of a mitochondrial‐targeted DNA editing enzyme that can specifically cleave the MERRF m.8344A>G mtDNA mutation. The novel feature of this enzyme is that it is monom
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Knockout of CMS-causative mitochondrial gene. Oryza sativa
To determine whether a mitochondrial gene orf312 causes Tadukan-type cytoplasmic male sterility using mitochondrial-targeted TALEN
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Predictability of DdCBEs mediated base editing in mitochondrial DNA
DdCBE acts as the most commonly used editor for mtDNA, our understanding of the editing rules is very limited, especially for the aC targets, we need to optimize the editing strategies by adjusting th
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