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Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 downregulation in lung and prostate cancers

NIAID Data Ecosystem2026-05-01 收录

神经内分泌机制

癌症靶向治疗

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE237074 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2023-10-11

癌症靶向治疗

RAS信号通路抑制

Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dual specificity mitogen-activated protein kinase kina

Protein Data Bank Japan2024-07-10 更新60

Table S2 from Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer

癌症靶向治疗

转录抑制响应

Disruption of the enzymatic activities of the transcription factor TFIIH by the small molecules Triptolide (TPL) or THZ1 could be used against cancer. Here, we used the MCF10A-ErSrc oncogenesis model

Figshare2020-06-01 更新30

Table S10 from EML4−ALK Variant-Specific Genetic Interactions Shape Lung Tumorigenesis

癌症靶向治疗

基因变异疗效评估

Supplementary Table 10 shows the proportional tumor size remaining after lorlatinib treatment, including the confidence intervals and significance.

Figshare2026-01-12 更新20

Depletion of Nrf2 in pancreatic cancer cells shifts arginine metabolism into the phosphocreatine energy system. Depletion of Nrf2 in pancreatic cancer cells shifts arginine metabolism into the phosphocreatine energy system

癌细胞重编程

癌症靶向治疗

Depletion of Nrf2 leads to an increase in cellular ROS, reduced glutathione and thiols, and profound reprogramming of metabolism. Unbiased transcriptome analyses show that key enzymes of glycolysis, p

NIAID Data Ecosystem60

Development of Aptamer-DNAzyme Based Metal-Nucleic Acid Frameworks for Gastric Cancer therapy

核酸适配体药物递送

癌症靶向治疗

All data from source data

NIAID Data Ecosystem20