Direct Catalytic Asymmetric Mannich-Type Reaction of β-Keto Phosphonate Using a Dinuclear Ni<sub>2</sub>−Schiff Base Complex
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Direct catalytic asymmetric Mannich-type reactions of β-keto phosphonates are described. A homodinuclear Ni2−Schiff base complex promoted the reaction at 0 °C, giving β-amino phosphonates in up to 90% yield, 20:1 dr, and 99% ee. Control experiments suggested that two Ni metals are important for achieving high yield and stereoselectivity.
创建时间：
2008-08-07
