Comparison of strand-biased mutation accumulation in the D-loop versus outside the D-loop (non–D-loop).

p-Values for differences in mutations frequencies of the two complementary mutation types, as well as between the D-loop and outside the D-loop (non–D-loop) were calculated with FET and corrected for multiple testing using the method of Benjamini–Hochberg to control the false discovery rate (separate for strand- and D-loop/non–D-loop comparisons). The “nt sequenced (type)” is the number of sequenced nucleotides that can effectively lead to the observed mutation type. FET, Fisher’s exact test. (XLSX)