ROS activates NETs release of bone marrow CD55+ neutrophils to promote early bone aging

NIAID Data Ecosystem2026-05-10 收录

骨衰老机制

中性粒细胞免疫

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https://www.ncbi.nlm.nih.gov/sra/SRP523897 数据链接链接失效反馈

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Bone marrow neutrophils are highly heterogeneous cells and we used sing cell RNA-sequencing to analyze the diversity of BM neutrophils of SAMP6 and SAMR1 mice femur bone. Overall design: Femour of 3-month male SAMP6 and SAMR1 mice were separately flushed out, and after lysing red cells, BM cells were analyzed by sc-RNA seq.

创建时间：

2025-12-02

Neutrophil gene expression in response to Mycobacterium abscessus

中性粒细胞免疫

病原体-宿主转录组互作

The response of human neutrophils to the emerging pathogen Mycobacterium abscessus has not been described. However, M. abscessus infections are frequently associated with neutrophil-rich abscesses.

NIAID Data Ecosystem80

Table_1_Caspase-8 activation in neutrophils facilitates autoimmune kidney vasculitis through regulating CD4+ effector memory T cells.xlsx

自身免疫性肾炎

中性粒细胞免疫

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are closely associated with neutrophil recruitment and activation, but the impact of the neutrophil apoptosis process in auto

NIAID Data Ecosystem30

DataSheet_1_Impact of bronchoalveolar lavage from influenza A virus diseased pigs on neutrophil functions and growth of co-infecting pathogenic bacteria.pdf

病毒-细菌共感染机制

中性粒细胞免疫

IntroductionInfluenza A viruses (IAVs) infect the respiratory tract of mainly humans, poultry, and pigs. Co-infections with pathogenic lung bacteria are a common event and contribute to the severity o

NIAID Data Ecosystem20

Single-cell RNA sequencing of healthy and inflamed murine neutrophils

单细胞转录组学

中性粒细胞免疫

Dataset containing single-cell RNA sequencing data of >17,000 healthy and perturbed murine neutrophils across biological tissues. This study contains expression data from healthy tissues (bone marrow,

NIAID Data Ecosystem60

This study describes the target receptor and mechanism of action of Staphylococcal superantigen like 13 (SSL13), a secret protein reside on S.aureus immune evasion cluster 2(IEC-2) that previously supposed to modulate immune evasion. In sharp contrast to the characterized SSLs located on the staphylococcal pathogenicity island 2 (SPI-2) , that inhibit immune functions, We demonstrate SSL13 is a chemoattractant and a neutrophil activator that acts via the FPR2. Therefore, SSL13 is a unique SSL member not belonging to the immune evasion class, but is a pathogen alarming molecule sensed by the FPR2. Our study provides a new conception of SSLs, that not only inhibit host immune processes but also recruit human neutrophils to the site of infection, where S. aureus can be disarmed by secreted immune evasion proteins and used as vesicles to other parts of the host. This allow us to better understand of S. aureus pathological processes.

金黄色葡萄球菌毒力

中性粒细胞免疫

Staphylococcal Superantigen-Like (SSL) proteins, one of major virulence factor families produced by Staphylococcus aureus, were previously demonstrated to be immune evasion molecules that interfere wi

NIAID Data Ecosystem30

ROS activates NETs release of bone marrow CD55+ neutrophils to promote early bone aging

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