Generating Un1Cas12f1-ABE via RNA-Protein Recruitment Modules

NIAID Data Ecosystem2026-05-10 收录

CRISPR碱基编辑

基因编辑工程优化

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP612172 数据链接链接失效反馈

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资源简介：

Optimization of the Un1Cas12f1-ABE constructs, sgRNA scaffold, and deaminase.

创建时间：

2026-01-14

Homo sapiens Genome sequencing. Homo sapiens

人类基因组编辑

CRISPR碱基编辑

Recently, base editors, composed of cytidine deaminase, Cas9 nickase (nCas9), and uracil DNA glycosylase inhibitor (UGI), have recently been developed to substitute a C at a target site with T without

NIAID Data Ecosystem70

CRISPR base editing of cis-regulatory elements enables target gene perturbations

CRISPR碱基编辑

基因表达调控

CRISPR technology has demonstrated broad utility for controlling target gene expression. However, there remains a need for strategies capable of modulating expression via the precise editing of non-co

NIAID Data Ecosystem40

Single CRISPR base editors to induce simultaneous C-to-T and A-to-G mutations

CRISPR碱基编辑

高通量测序

High-throughput sequencing data of CRISPR base editing assays in human cells

NIAID Data Ecosystem30

Highly efficient CRISPR-mediated base editing for the gut Bacteroides spp. with pnCasBS-CBE

肠道菌群基因编辑

CRISPR碱基编辑

We constructed a pnCasBS-CBE system for base editing in the Bacteroides thetaiotaomicron to expand their genetic toolkit, which can efficiently convert a C:G to a T:A in the genome. As a functional pr

NIAID Data Ecosystem40

Table_1_Highly Efficient CRISPR-Mediated Base Editing in Sinorhizobium meliloti.DOCX

CRISPR碱基编辑

根瘤菌基因组操作

Rhizobia are widespread gram-negative soil bacteria and indispensable symbiotic partners of leguminous plants that facilitate the most highly efficient biological nitrogen fixation in nature. Although

NIAID Data Ecosystem30

Generating Un1Cas12f1-ABE via RNA-Protein Recruitment Modules

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