Absence of gut microbial colonization attenuates the sympathoadrenal response to hypoglycemia in mice

Gut microbiota plays an important role during early development via bidirectional gut- brain signaling. We aimed to explore the potential link between gut microbiota/gut derived metabolites and sympathoadrenal stress responsivity The reponse to insulin induced hypoglycemia was compared in normally colonized male mice (control, C) and sterile male (germ free mice, GF) of the same genetic background (C57Bl6) using whole genome transcriptome profyling of adrenal medullary RNA samples.