Nasal polyp tissue (n = 9) was incubated with FF and MF at different concentrations for 1 hour, and then washed and SEB was added immediately (0 hour), after 6 or 24 hours (pre-challenge incubation with time interval).

Cells were then incubated for another 24 hours. When SEB stimulation was performed immediately, FF demonstrated a faster onset of action with a significantly higher maximal inhibition of all cytokines vs. MF. For most cytokines and time points, FF reached a significant reduction at a lower concentration; however, when the time interval between pre-incubation and challenge was minimally 6 hours, the suppression capacity of MF reached the same levels as FF for IL-5 and TNF-α.N = no significant reduction reached at any concentration tested.