首页/数据集/MiR-150 Suppresses MLL-AF9 Associated Leukemia Through Simultaneously Targeting Multiple Oncogenes

MiR-150 Suppresses MLL-AF9 Associated Leukemia Through Simultaneously Targeting Multiple Oncogenes

ChEBI2011-07-19 更新2026-07-21 收录

白血病靶向治疗

微小RNA功能机制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-30771 数据链接链接失效反馈

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资源简介：

MiR-150 Suppresses MLL-AF9 Associated Leukemia Through Simultaneously Targeting Multiple Oncogenes

应用场景：

创建时间：

2011-07-19

白血病靶向治疗

ATP（三磷酸腺苷）

The chromatin-associated AAA+ ATPases Tip48 and Tip49 are the core components of various complexes implicated in diverse nuclear events such as DNA repair and gene regulation. Although they are freque

NIAID Data Ecosystem60

Targeting nucleoporin 214 selectively eliminates leukemia stem cells

白血病靶向治疗

核孔蛋白功能研究

LSCs from MLL-AF9-driven Nup214fl/fl and Nup214fl/fl,Tie2-Cre AML mice were sorted, followed by further proteomic assay.

NIAID Data Ecosystem20

Genetic or pharmacological inactivation of CREBBP sensitizes B-cell Acute Lymphoblastic Leukemia to Ferroptotic Cell Death upon BCL2 Inhibition. Genetic or pharmacological inactivation of CREBBP sensitizes B-cell Acute Lymphoblastic Leukemia to Ferroptotic Cell Death upon BCL2 Inhibition

白血病靶向治疗

铁死亡机制

We performed a targeted drug screen in isogenic human cell lines, identifying a number of actionable small molecules that specifically target CREBBP-mutated B-ALL. The most potent was the BCL2 inhibit

NIAID Data Ecosystem20

Albumin binding domain fused to a mutant of the Erwinia asparaginase

蛋白质工程药物设计

白血病靶向治疗

Albumin binding domain fused to a mutant of the Erwinia asparaginase Descriptor: ASPARTIC ACID, L-asparaginase Authors: Lavie, A, Nguyen, H.A. Deposit date: 2022-03-04 Release date: 2022-08-31 Last mo

Protein Data Bank Japan2024-10-23 更新30

A potent and selective small-molecule degrader of ENL suppresses leukemia progression in vivo (ChIP-Seq)

白血病靶向治疗

蛋白降解靶向嵌合体

ENL, a stoichiometric component of the Super Elongation Complex (SEC) as well as the histone H3K79 methyltransferase DOT1L complex, is involved in the regulation of transcription elongation. Loss-of-f

NIAID Data Ecosystem20

MiR-150 Suppresses MLL-AF9 Associated Leukemia Through Simultaneously Targeting Multiple Oncogenes

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