We performed a genome-wide CRISPR knockout screen to identify human genes required for SARS-CoV-2 infection. Overall design: Human Huh7 CRISPR-Cas9 perturbed cells were infected with SARS-CoV-2 at low
Aim: The aim of this study was to identify host factors that interact with the 5? end of the MERS-CoV RNA genome. Materials & methods: RNA affinity chromatography followed by mass spectrometry ana
BT20 (TNBC) cells were cultured with either DMSO (v/v%) or Erlotinib (10uM) for 24 hours to observe differential expression changes between conditions. CAS-9 expressing BT20 (TNBC) cells were transduc
Raw counts of CRISPR/Cas9 activation screens using the Calabrese library upon regorafenib or DMSO treatment in GS-9, LN229, LN18, LNZ308, and T98G glioma cell lines
Following nearly five decades with few approved therapies for acute myeloid leukemia (AML), the last three years have brought stellar progress with the U.S. Food and Drug Administration approving a nu