B-Raf V600E kinase domain in complex with an aminoisoquinoline inhibitor
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B-Raf V600E kinase domain in complex with an aminoisoquinoline inhibitor Descriptor: B-Raf proto-oncogene serine/threonine-protein kinase, N~1~-(4-chlorophenyl)-6-methyl-N~5~-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine Authors: Whittington, D.A, Epstein, L.F. Deposit date: 2009-07-21 Release date: 2009-10-06 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Selective inhibitors of the mutant B-raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline. J.Med.Chem., 52, 2009
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2009-07-21
