Three-dimensional connectivity and chromatin environment mediate the activation efficiency of mammalian DNA replication origins. Three-dimensional connectivity and chromatin environment mediate the activation efficiency of mammalian DNA replication origins

Genome-wide detection of replication origins by sequencing of short nascent strands (SNS) purified from mouse embryonic stem cells (mESCs). Overall design: Replication origins were mapped in mESCs grown in control and stress conditions induced by aphidicolin or CDC6 overexpression