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RNA 5-methylcytosine orchestrates HSPC expansion in zebrafish (PRJCA021985)

NIAID Data Ecosystem2026-05-10 收录

RNA表观遗传学

造血发育生物学

数据链接：

https://www.ncbi.nlm.nih.gov/sra/DRP015370 数据链接链接失效反馈

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资源简介：

Using RNA bisulfite sequencing (RNA-BisSeq) and RNA-sequencing, we profiled the dynamic changes of mRNA m5C modification during HSPC development in zebrafish.

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创建时间：

2025-12-05

细胞轨迹推断

造血发育生物学

This repository contains the precomputed simulation data and preprocessed hematopoiesis datasets used in the paper "Global StationaryOT: Trajectory inference for aging time courses of single-cell snap

Zenodo2026-01-17 更新60

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (MeRIP-Seq)

RNA表观遗传学

细胞染色质调控

N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in he

NIAID Data Ecosystem50

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny. Homo sapiens

造血发育生物学

单细胞转录组学

In a classical view of hematopoiesis, the various blood cell lineages arise via a hierarchical scheme starting with multipotent stem cells that become increasingly restricted in their differentiation

NIAID Data Ecosystem40

Additional file 3 of Dissecting the sequence and structural determinants guiding m6A deposition and evolution via inter- and intra-species hybrids

RNA表观遗传学

种间杂交

Additional file 3: The m6A-peaks detected throughout this study in the yeast strains (Table S3), human-mice interspecies hybrid system (Table S4) and mice-mice intraspecies hybrid system (Table S5).

Figshare2024-08-18 更新60

M6A IP from BrU-labeled and fragmented nascent RNA.

RNA表观遗传学

M6A修饰检测

M6A immunoprecipitation from 15min BrU labeled and fragmented nascent RNA. HEK293T cells were incubated with 2 mM bromouridine for 15 min labeling time (pulse). Whole-cell total RNA was extracted with

NIAID Data Ecosystem40

RNA 5-methylcytosine orchestrates HSPC expansion in zebrafish (PRJCA021985)

资源简介：

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