This thesis utilises super-resolution microscopy to visualise the spatial organisation of the nucleus in immune T cells. It identifies that the nucleus is remodelled and reconfigured as it transitions
Cell differentiation is based on a synchronised orchestra of complex pathways of intrinsic and extrinsic signals that manifest in the induced expression of specific transcription factors and pivotal g
It is now well established that transcriptional enhancers dictate with high precision lineage-specific programs of gene expression. However, it has remained an enigma as to how distally located enha
