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Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility. Ng et al.

NIAID Data Ecosystem2026-05-10 收录

免疫代谢

T细胞功能表观遗传

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https://data.mendeley.com/datasets/b2yktg2b92 数据链接链接失效反馈

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资源简介：

Processed metabolomics data, histone modifications by LC-MS, pharmacokinetics, proximity ligation images, and uncropped western blots.

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创建时间：

2026-03-13

病毒-宿主相互作用

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An increasing body of evidence emphasizes the role of metabolic reprogramming in immune cells to fight off infections. However, little is known about the regulation of metabolite transporters that fac

NIAID Data Ecosystem100

DataSheet_1_Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model.zip

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PD-1联合治疗

IntroductionThe discovery of immune checkpoints and the development of their specific inhibitors was acclaimed as a major breakthrough in cancer therapy. However, only a limited patient cohort shows s

NIAID Data Ecosystem30

Requirement of mitochondrial transcription factor A in interleukin-17-producing gdT cells to regulate the small intestine homeostasis and metabolism. Requirement of mitochondrial transcription factor A in interleukin-17-producing gdT cells to regulate the small intestine homeostasis and metabolism

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小肠稳态调节

Interleukin 17 (IL-17)-producing gamma delta T (gdT17) cells are one of the major cellular sources of IL-17 under the steady state and in disease. However, gdT17 cell metabolism and its role in tissue

NIAID Data Ecosystem30

D- 2-hydroxyglutarate is an immunometabolite that accumulates in macrophages after TLR activation and inhibits inflammatory responses

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巨噬细胞炎症抑制

Macrophages undergo extensive metabolic rewiring upon activation and this serves many roles beyond the production of energy and anabolic building blocks. So-called immunometabolites that accumulate up

NIAID Data Ecosystem30

Transcriptome profiling of mouse CD8+ T cells in the presence or absence of acetate

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转录组分析

To investigate the role of acetate in T cell survival and the underlying mechanism, transcription profiling was performed on mouse CD8+ T cells treated with or without 10mM acetate for 24h. We then pe

NIAID Data Ecosystem30

Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility. Ng et al.

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