Abrogation of G10-Mediated Antiviral Activity and ISG Expression in Cells Lacking STAT1.
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(A) Average media titers ±SD of CHIKV, VEEV, and SINV at 24h (VEEV) or 48h (CHIKV, SINV) obtained from THF-ISRE-ΔSTAT1 cells treated with 1% DMSO, 100μM G10, or 1000U/mL IFNβ as indicated. Infections were performed in triplicate. (B) Synthesis of Mx2 and ISG56 proteins in THF-ISRE and THF-ISRE-ΔSTAT1 following 24h exposure to SeV, UV-CMV, 1000U/mL IFNβ or 100μM G10 as indicated.
创建时间：
2016-02-23
