Inhibition of inflammasome and pyroptotic pathways are promising strategies for clinical treatment of autoimmune and inflammatory disorders. MCC950, a potent inhibitor of the NLR-family inflammasome p

NIAID Data Ecosystem40

Proteomics of BRAFi-treated endothelial cells

药物脱靶效应

细胞信号传导

Targeted therapies against mutant BRAF are effectively used in combination with MEK inhibitors (MEKi) to treat advanced melanoma. However, treatment success is affected by resistance and adverse event

NIAID Data Ecosystem20

Estimating Genome-wide Off-Target Effects for Pyrrole-Imidazole Polyamide Binding by a Pathway-Based Expression Profiling Approach (SiHA cells)

药物脱靶效应

药物发现基因组学

Side and off-target effects remain a difficult issue in the search of pharmaceutical leads, especially with DNA-binding molecules or genome editing methods where the issue becomes particularly thorny.

NIAID Data Ecosystem40

XMD8-92 and JWG-045 exhibit anti-ferroptotic activities, independently of inhibiting ERK5

铁死亡机制

药物脱靶效应

Extracellular-regulated protein kinase 5 (ERK5) is a promising target in cancer therapy, and several ERK5 inhibitors have been developed. In this study, we observed that the inhibitors XMD8-92 and JWG

NIAID Data Ecosystem30

Proteome-wide map of targets of T790M-EGFR-directed covalent inhibitors

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