Cardiac gene expression profiling of heart failure treatment with the anti-ischemic drug ranolazine

ChEBI2010-12-03 更新2026-07-21 收录

药物机制研究

心脏疾病分子机制

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-25766 数据链接链接失效反馈

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Cardiac gene expression profiling of heart failure treatment with the anti-ischemic drug ranolazine

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2010-12-03

Top three gene ontology biological processes resulting from the analysis of differential regulated genes between antioxidant drugs and the respective solvent controls.

基因本体富集分析

药物机制研究

This analysis was performed using the DAVID program (see MM). Count indicates the number of genes belonging to the indicated gene ontology biological processes that we found regulated by a factor 2; %

NIAID Data Ecosystem60

CDK4/6 inhibitors induce repication stress to cause long-term cell cycle withdrawal

细胞周期调控

药物机制研究

CDK4/6 inhibitors arrest the cell cycle in G1-phase. They are licenced to treat breast cancer and are also undergoing clinical trials against a range of other tumour types. To facilitate these efforts

NIAID Data Ecosystem60

The IC 50 of the inhibitory effect of tylophora alkaloids on NF-κB, AP-1, and CRE signalging pathways in HepG2 and HEK-293 cells.

信号通路抑制

药物机制研究

Values are means ± SD of at least three experiments, with each data point done in triplicate. The IC50 concentrations of these compounds are significantly different (p<0.05) from each other in between

NIAID Data Ecosystem40

Inhibition of BRD4 Rescues Cardiac phenotype in Myocyte-Specific Lamin A/C Null Mice

心脏疾病分子机制

基因治疗研究

Deletion of Lmna, encoding nuclear membrane protein LMNA, specifically in mouse cardiac myocytes activates BRD4 and leads to heart failure, arrhythmias, myocardial fibrosis, apoptosis, and premature d

NIAID Data Ecosystem60

Additional file 2: of Transcriptome analysis of human heart failure reveals dysregulated cell adhesion in dilated cardiomyopathy and activated immune pathways in ischemic heart failure

心力衰竭转录组学

心脏疾病分子机制

Table S2. RNAseq quality control table. Raw read counts ranged from ~â 36 to 66 million. Read counts show a 99% retention after base quality control and a 94â 96% alignment rate. (XLSX 16Â kb)

Figshare2018-11-13 更新60

Cardiac gene expression profiling of heart failure treatment with the anti-ischemic drug ranolazine

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