FerrDb V2

FerrDb V2 contains 1001 ferroptosis regulators and 143 ferroptosis-disease associations manually curated from 3288 articles. Specifically, there are 621 gene regulators, of which 264 are drivers, 238 are suppressors, 9 are markers, and 110 are unclassified genes; and there are 380 substance regulators, with 201 inducers and 179 inhibitors. Compared to FerrDb V1, curated articles increase by > 300%, ferroptosis regulators increase by 175%, and ferroptosis-disease associations increase by 50.5%. Circular RNA and pseudogene are novel regulators in FerrDb V2, and the percentage of non-coding RNA increases from 7.3% to 13.6%. External gene-related data were integrated, enabling thought-provoking and gene-oriented analysis in FerrDb V2.

FerrDb V2 包含1001个铁死亡（ferroptosis）调控因子与143条经人工审编自3288篇文献的铁死亡-疾病关联数据。具体而言，该数据集涵盖621个基因类调控因子，其中264个为驱动因子、238个为抑制因子、9个为标记因子，另有110个未分类基因；同时包含380个物质类调控因子，涵盖201种诱导剂与179种抑制剂。相较于FerrDb V1，本次版本的人工审编文献量增幅超300%，铁死亡调控因子数量增长175%，铁死亡-疾病关联数据增加50.5%。环状RNA（circular RNA）与假基因（pseudogene）为FerrDb V2新增的调控因子类型，非编码RNA（non-coding RNA）的占比从7.3%提升至13.6%。此外，FerrDb V2整合了外部基因相关数据，可支持富有启发性的基因导向型分析。

搜集汇总

背景与挑战

背景概述

FerrDb V2 是一个专门收录铁死亡调节因子及其与疾病关联的数据库，包含1001个调节因子和143个关联。这些调节因子分为基因（包括驱动因子、抑制因子、标志物和未分类基因）和物质（包括诱导剂和抑制剂）两大类。