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<i>N</i><sup>2</sup>‑Selective Iodofunctionalization of Olefins with <i>NH</i>-1,2,3-Triazoles to provide <i>N</i><sup>2</sup>‑Alkyl-Substituted 1,2,3-Triazoles

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A new method was developed to synthesize N2-alkyl-substituted 1,2,3-triazole through N-iodosuccinimide (NIS) mediated iodofuctionalization reaction of the alkene group with bi-, mono-, and unsubstituted NH-1,2,3-triazoles. The favored N-1 type hydrogen bond between the iodonium ion intermediate and 1,2,3-triazole was supposed to be generated, which gave the desired N2-alkyl triazole with a high N2-selectivity.

创建时间:
2016-05-02
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