Background Botulism is a disease caused by neurogenic toxins that block acetylcholine release, resulting in potentially life threatening neuroparalysis. Seven distinct serotypes of botulinum neurotoxi
We evaluate heterozygous transgenic mice expressing human ACE2 receptor driven by the epithelial cell promoter cytokeratin-18 promoter (K18-hACE2) as a model of SARS-CoV-2 infection. Intranasal inocul
aVirus titers of the other animals in the group could not be determined. bThe range of the cut off values is the range of the cut off values of the individual animals. nd, not determined.
a BALB/c mice were inoculated i.n. with 106 CCID50 of the Ah01/H7N9 or Ah01/AA ca virus or phosphate-buffered saline (control). These animals were euthanized 3 days after inoculation. Virus titers in
No single animal model for severe acute respiratory syndrome (SARS) reproduces all aspects of the human disease. Young inbred mice support SARS-coronavirus (SARS-CoV) replication in the respiratory tr
