Gene Ontology enrichment analyses of genes showing the greatest increase and decrease in expression following adaptation.

Genes +/?1.5 SD from the mean of summed expression changes across all experiments were analyzed for statistically significant GO term enrichment by computing a p-value using the hypergeometric distribution (The background set of genes was 5443, the number measured in microarray experiments). Nonredundant, statistically significant enriched GO terms (Bonferonni corrected pclass) were divided by the number of genes within the genome that are annotated to that GO term (Ngenome) to determine a fractional representation of each term (%).