Among the four Argonaute family members in mammals, only AGO2 protein retains endonuclease activity, and facilitates cleavage of target RNAs base-pairing with highly complementary guide RNAs. Despite
AiPD is the first curated repository for autoinhibited proteins, standardizing data on 698 experimentally validated autoinhibitory domains (AIDs), 42,520 predicted AIDs, regulatory mechanisms, disease
