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RNA-seq of small intestinal organoids treated with an inhibitor for the epigenetic modifier LSD1

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NIAID Data Ecosystem2026-05-01 收录
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To assess the role of LSD1 in mice small intestinal epithelium, small intestinal organoids were treated with an inhibitor for LSD1 (GSK-LSD1) and compared to untreated organoids. Similar to intestinal epithelium from mice with an intestinal epithelium specific LSD1-KO, paneth cells dissappear upon GSK-LSD1 treatment. We used these sequencing data to show that these small intestinal organoids have a similar phenotype as mice epithelium without LSD1.

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2023-10-13
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