Whole-genome sequence analysis and comparisons between genotypic heteroresistance and minimum inhibitory concentrations of Mycobacterium tuberculosis isolates causing M/XDR-TB

Drug resistance remains a major challenge for tuberculosis control. Whole-genome sequencing (WGS) provides the highest genetic resolution for drug susceptibility tests (DST). We compared drug-susceptibility profiles of 62 M. tuberculosis isolates based on agar proportion, minimum inhibitory concentration (MIC) test and a WGS-based DST.