Crystal structure of p53 cancer mutant Y220C in complex with rezatapopt

Crystal structure of p53 cancer mutant Y220C in complex with rezatapopt Descriptor: 1,2-ETHANEDIOL, 4-[3-[4-[[(3~{S},4~{R})-3-fluoranyl-1-methyl-piperidin-4-yl]amino]-1-[2,2,2-tris(fluoranyl)ethyl]indol-2-yl]prop-2-ynylamino]-3-methoxy-~{N}-methyl-benzamide, Cellular tumor antigen p53, ... Authors: Mavridi, D, Balourdas, D.I, Joerger, A.C, Structural Genomics Consortium (SGC) Deposit date: 2025-08-06 Release date: 2026-03-11 Last modified: 2026-04-01 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Targeting the p53 cancer mutants Y220C, Y220N, and Y220S with the small-molecule stabilizer rezatapopt. Cell Death Dis, 17, 2026