Next Generation Sequencing of scWAT from WT and Yapfl/fl/Tazfl/fl;AdipoqCre mice

YAP, TAZ are transcriptional co-regulators involved in many important biological processes. But the functional roles in adipocytes are not well understood. So we sequenced the mRNA of scWAT deleted of Yap/Taz simulataneously to explore the roles of YAP/TAZ in adipocytes. Comparative profiling analysis of gene expression based on RNA-seq data of scWAT from 8 weeks old male WT and Yapfl/fl/Tazfl/fl;AdipoqCre mice.YAP、TAZ是参与诸多重要生物学过程的转录共调控因子（transcriptional co-regulators），但其在脂肪细胞中的功能角色尚未得到充分阐明。为此，我们对同时敲除Yap/Taz的皮下白色脂肪组织（subcutaneous white adipose tissue，缩写scWAT）的信使RNA（messenger RNA，缩写mRNA）进行了测序，以探究YAP/TAZ在脂肪细胞中的功能作用。基于8周龄雄性野生型（wild type，缩写WT）小鼠与Yapfl/fl/Tazfl/fl;AdipoqCre小鼠的scWAT RNA测序（RNA sequencing，缩写RNA-seq）数据，我们开展了基因表达比较谱分析。