Dataset for the Effects of 28-Day Nose-Only Inhalation of PCB52 (2,2’,5,5’-Tetrachlorobiphenyl) on the Brain Transcriptome

This dataset includes the data from a study investigating the effects of inhaled PCB52 on the adolescent brain. This study used adolescent Sprague-Dawley rats to determine the neurological effects of a subacute (28-day) PCB52 inhalation exposure. Rats were exposed 4 h a day for 28 consecutive days with neurobehavioral tests conducted during the last 5 days of exposure. Based on the data including body weight and tissue weights, PCB52 and metabolite levels (target and non-target analyses), gene expression in the striatum and cerebellum, and neurobehavioral tests [Y-maze, hole board test (HBT), open field test (OFT), and elevated plus maze (EPM)], brain immunohistochemistry images; a subacute inhalation of PCB52 results in multilevel effects of inhaled PCB52 on the rat brain, from gene expression to behavioral effects.