The RUNX genes encode for transcription factors involved in development and human disease. RUNX1 and RUNX3 are frequently associated with leukemias, yet the basis for their involvement in leukemogenes
To generate antibodies with different effector functions, B cells undergo Immunoglobulin class switch recombination (CSR). The ligation step of CSR is usually mediated by the classical non-homologous
The potential for human disease treatment using human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells (iPSCs), also carries the risk of added genomic instabil
Sequencing of offspring tails from TP63-/- female mice irradiated with 45Gy and non irradiated controls to determine mutation rate at a dose that sterilises wild type mice.Despite mobilizing the DNA r
Sequencing of offspring tails from TP63-/- female mice irradiated with 45Gy and non irradiated controls to determine mutation rate at a dose that sterilises wild type mice.Despite mobilizing the DNA r
