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Enantioselective Spirocyclizations from Tryptophanol-Derived Oxazolopiperidone Lactams

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NIAID Data Ecosystem2026-03-06 收录
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A straightforward synthetic route to enantiopure spiro[indole-3,3‘-indolizidines] is reported. The key step is a Lewis acid promoted cyclization of a Na-tosyltryptophanol-derived oxazolopiperidone lactam in the presence of Et3SiH.

创建时间:
2016-06-03
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