CRISPR_off_target_screening_in_mice___WES

NIAID Data Ecosystem2026-03-12 收录

CRISPR脱靶检测

基因编辑安全性

数据链接：

https://www.ncbi.nlm.nih.gov/sra/ERP015061 数据链接链接失效反馈

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资源简介：

POT1 mutant mice were generated using CRISPR. In this study we wish to use WES to look for off-target mutations.

创建时间：

2021-02-04

Table_3_Gene Editing and Genotoxicity: Targeting the Off-Targets.XLSX

基因编辑安全性

脱靶效应检测

Gene editing technologies show great promise for application to human disease as a result of rapid developments in targeting tools notably based on ZFN, TALEN, and CRISPR-Cas systems. Precise modifica

NIAID Data Ecosystem80

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases

基因编辑安全性

核酸酶脱靶检测

We describe a robust linear amplification-mediated high-throughput genome-wide translocation sequencing (HTGTS) method that identifies endogenous or ectopic "prey" DNA double-stranded breaks (DSBs) ac

NIAID Data Ecosystem70

CRISPR-mediated biocontainment: Data for figure S2

基因编辑安全性

细胞疗法安全评估

Leveraging transposable elements of the genome to prevent Cas9 editing and design a safety-switch for cell therapies

NIAID Data Ecosystem50

Optimizing genome editing strategy by primer-extension-mediated sequencing

CRISPR脱靶检测

基因组优化

High specificity of e\ngineered nucleases ensures precise genome editing. Couple methods were developed to identify off-target sites of CRISPR/Cas9, but hardly any high-throughput sequencing method ca

NIAID Data Ecosystem70

Genotoxic effects of base and prime editing in human hematopoietic stem cells [WES opt]

基因编辑安全性

造血干细胞

Emerging base and prime editing may provide safer and more precise genetic engineering than nuclease-based approaches bypassing the dependence on DNA double strand breaks (DSBs). However, little is kn

NIAID Data Ecosystem60

CRISPR_off_target_screening_in_mice___WES

资源简介：

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