Highly Enantio- and Diastereoselective Mannich Reactions of Chiral Ni(II) Glycinates with Amino Sulfones. Efficient Asymmetric Synthesis of Aromatic α,β-Diamino Acids

This paper describes a practical, enantio- and diastereoselective Mannich reaction between a chiral Ni(II) complex of glycine 1 and α-amino sulfones 2, involving the creation of a carbon−carbon bond and two stereogenic centers in a single operation; it represents an attractive route to the synthesis α,β-diamino acids.