Multicomponent Mannich Reactions with Boron Enolates Derived from Diazo Esters and 9-BBN
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Diazo esters, arylboranes, and carbamoyl imines undergo a 3-component Mannich condensation reaction. Catalyzed by Cu(II) salts, the reaction affords the corresponding isocyanate Mannich product: one that can be easily trapped in situ by other nucleophiles. The Mannich condensation corresponds to an α,α-disubstituted enolate addition to imines. The reaction was rendered asymmetric by using the (−)-phenylmenthol ester in good yield and selectivities.
创建时间：
2016-02-23
