Access to P‑Stereogenic Phosphinates via N‑Heterocyclic Carbene-Catalyzed Desymmetrization of Bisphenols
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A carbene-catalyzed desymmetrization of prochiral bisphenol compounds bearing remote P-stereogenic centers is disclosed. The catalytic reactions can be performed on gram scales with 1 mol % N-heterocyclic carbene (NHC) catalyst, providing efficient access to enantiomerically enriched P-stereogenic phosphinates. The chiral phosphinates prepared with our method can find widespread applications as asymmetric organic catalysts and ligands.
创建时间：
2016-06-17
