Crystal structure of the human METTL3-METTL14 in complex with small molecule inhibitor Compound 59

Crystal structure of the human METTL3-METTL14 in complex with small molecule inhibitor Compound 59 Descriptor: 4-[(3~{R})-3-(cyclopropylmethylamino)piperidin-1-yl]-1-[(1~{R})-1-[4-(6-pyrrolidin-1-ylpyrazin-2-yl)-1,2,3-triazol-1-yl]ethyl]pyridin-2-one, CALCIUM ION, N6-adenosine-methyltransferase catalytic subunit, ... Authors: Dutheuil, G, Oukoloff, K. Deposit date: 2024-07-16 Release date: 2025-02-12 Last modified: 2025-08-27 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Discovery, Optimization, and Preclinical Pharmacology of EP652, a METTL3 Inhibitor with Efficacy in Liquid and Solid Tumor Models. J.Med.Chem., 68, 2025